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Data
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An ion-based model for swelling of neurons and astrocytes (Hubel & Ullah 2016)
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Niklas Hübel
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The programs describe ion dynamics and osmosis-driven cellular swelling. “code_fig3.ode” shows a
scenario of permanent cessation of energy supply / Na/K-pump activity, and the induced transition from
normal conditions to the Donnan equilibrium for an isolated neuron and its extracellular space.
“code_Fig7.ode” shows spreading depolarization induced by an interruption of energy supply in a model
consisting of a neuron, a glia cell and the extracellular space. The simulations show the evolution of ion
concentrations, Nernst potentials, the membrane potential, gating variables and cellular volumes.
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niklas.huebel@gmail.com
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Hübel, N. and Ullah, G., "Anions Govern Cell Volume: a Case Study of Relative Astrocytic and Neuronal Swelling in Spreading Depolarization", PLoS ONE, 10.1371/journal.pone.0147060 (2016)
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