BrainPharm: Computational model - Endocannabinoid dynamics gate spike-timing dependent depression and potentiation (Cui et al 2016)

Computational model

Data

Name

Endocannabinoid dynamics gate spike-timing dependent depression and potentiation (Cui et al 2016)

Submitter name

Ilya Prokin

Pipeline ID

Model File

STDP_model [798078]

Notes

The endocannabinoid (eCB) system is considered involved in synaptic depression. Recent reports have also linked eCBs to synaptic potentiation. However it is not known how eCB signaling may support such bidirectionality. To question the mechanisms of this phenomena in spike-timing dependent plasticity (STDP) at corticostriatal synapses, we combined electrophysiology experiments with biophysical modeling. We demonstrate that STDP is controlled by eCB levels and dynamics: prolonged and moderate levels of eCB lead to eCB-mediated long-term depression (eCB-tLTD) while short and large eCB transients produce eCB-mediated long-term potentiation (eCB-tLTP). Therefore, just like neurotransmitters glutamate or GABA, eCB form a bidirectional system.

Model Neurons

Neostriatum medium spiny direct pathway GABA cell Show Other
Neostriatum medium spiny indirect pathway GABA cell Show Other

More Cells

Neostriatum spiny neuron Show Other

Model Currents

I L high threshold Show Other
I Calcium Show Other
I_SERCA Show Other
I Cl, leak Show Other
Ca pump Show Other

Model Receptors

AMPA Show Other
NMDA Show Other
mGluR Show Other
Glutamate Show Other
IP3 Show Other

Model Type

Synapse Show Other
Channel/Receptor Show Other

Model Concept

Ion Channel Kinetics Show Other
Coincidence Detection Show Other
Parameter Fitting Show Other
Synaptic Plasticity Show Other
Long-term Synaptic Plasticity Show Other
Signaling pathways Show Other
STDP Show Other
Calcium dynamics Show Other
Parameter sensitivity Show Other
G-protein coupled Show Other
Neuromodulation Show Other

Simulator software

FORTRAN Show Other
Python Show Other

Model papers

Cui Y, Prokin I, Xu H, Delord B, Genet S, Venance L, Berry H (2016) Show Other

Gene

hg folder name (applicable when in ModelDB hg)

Region Organism

Model ID Number

Gap Junctions

Implemented by

Public Submitter Email Address

isprokin@gmail.com

Other Neuron

Model Neurotransmitters

Other Receptor

CB1R

Other Current

I_TRPV1

Other Neurotransmitter

Other Model Type

Other Concept

Other Simulator

Other Implementer

Alternative Version

Citation

Default File Notes

Other Gene

Simulation Platform ID

Has Model View

False

Component

RAM

Hide Auto-launch button

False

Run Protocols

ICG Channel Details

Species

Other categories referring to Endocannabinoid dynamics gate spike-timing dependent depression and potentiation (Cui et al 2016)

Revisions:	13
Last Time:	1/13/2017 12:21:27 PM
Reviewer:	Tom Morse - MoldelDB admin
Owner:	Tom Morse - MoldelDB admin