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Data
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CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)
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Mark Cembrowski
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"... We examined synaptic connectivity
between molecularly defined inhibitory interneurons
and CA1 pyramidal cell dendrites using
correlative light-electron microscopy and large-volume
array tomography. We show that interneurons
can be highly selective in their connectivity to specific
dendritic branch types and, furthermore,
exhibit precisely targeted connectivity to the origin
or end of individual branches. Computational simulations
indicate that the observed subcellular
targeting enables control over the nonlinear integration
of synaptic input or the initiation and
backpropagation of action potentials in a branchselective
manner. Our results demonstrate that
connectivity between interneurons and pyramidal
cell dendrites is more precise and spatially segregated
than previously appreciated, which may be
a critical determinant of how inhibition shapes dendritic
computation."
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Hippocampus CA1 pyramidal GLU cell Show
Other
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Neuron or other electrically excitable cell Show
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Bloss EB, Cembrowski MS, Karsh B, Colonell J, Fetter RD, Spruston N (2016) Show
Other
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Cembrowski, Mark S [cembrowskim at janelia.hhmi.org] Show
Other
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cembrowskim@janelia.hhmi.org
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