BrainPharm: Computational model - Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)

Computational model

Data

Name

Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)

Submitter name

Pipeline ID

Model File

dystdemo [262730]

Notes

" ... We developed a multiscale model of primary motor cortex, ranging from molecular, up to cellular, and network levels, containing 1715 compartmental model neurons with multiple ion channels and intracellular molecular dynamics. We wired the model based on electrophysiological data obtained from mouse motor cortex circuit mapping experiments. We used the model to reproduce patterns of heightened activity seen in dystonia by applying independent random variations in parameters to identify pathological parameter sets. ..."

Model Neurons

Neocortex L5/6 pyramidal GLU cell Show Other
Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell Show Other
Neocortex V1 interneuron basket PV GABA cell Show Other

More Cells

Neocortex fast spiking (FS) interneuron Show Other
Neocortex spiking regular (RS) neuron Show Other
Neocortex spiking low threshold (LTS) neuron Show Other
Neocortex layer 4 neuron Show Other
Neocortex layer 2-3 interneuron Show Other
Neocortex layer 4 interneuron Show Other
Neocortex layer 5 interneuron Show Other
Neocortex layer 6a interneuron Show Other

Model Currents

I A Show Other
I h Show Other
I_SERCA Show Other
Ca pump Show Other
I K,Ca Show Other
I Calcium Show Other
I L high threshold Show Other
I T low threshold Show Other
I N Show Other
I_KD Show Other
I M Show Other
I Na,t Show Other

Model Receptors

GabaA Show Other
GabaB Show Other
AMPA Show Other
mGluR Show Other

Model Type

Realistic Network Show Other
Molecular Network Show Other

Model Concept

Oscillations Show Other
Activity Patterns Show Other
Beta oscillations Show Other
Reaction-diffusion Show Other
Calcium dynamics Show Other
Pathophysiology Show Other
Multiscale Show Other

Simulator software

NEURON Show Other
Python Show Other

Model papers

Neymotin SA, Dura-Bernal S, Lakatos P, Sanger TD, Lytton WW (2016) Show Other

Gene

HCN1 Show Other

hg folder name (applicable when in ModelDB hg)

dystdemo

Region Organism

Neocortex Show Other

Model ID Number

Gap Junctions

Implemented by

Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org] Show Other
Dura-Bernal, Salvador [salvadordura at gmail.com] Show Other

Public Submitter Email Address

Other Neuron

Model Neurotransmitters

Gaba Show Other
Glutamate Show Other

Other Receptor

Other Current

I_KDr

Other Neurotransmitter

Other Model Type

Other Concept

Drug Discovery, Dystonia

Other Simulator

Other Implementer

Alternative Version

Citation

Default File Notes

Other Gene

Simulation Platform ID

Has Model View

False

Component

RAM

Hide Auto-launch button

True

Run Protocols

ICG Channel Details

Species

Other categories referring to Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)

Revisions:	15
Last Time:	5/27/2022 12:23:42 PM
Reviewer:	System Administrator
Owner:	Tom Morse - MoldelDB admin