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Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
dystdemo_r1 [239126]
" ... We developed a multiscale model of primary motor cortex, ranging from molecular, up to cellular, and network levels, containing 1715 compartmental model neurons with multiple ion channels and intracellular molecular dynamics. We wired the model based on electrophysiological data obtained from mouse motor cortex circuit mapping experiments. We used the model to reproduce patterns of heightened activity seen in dystonia by applying independent random variations in parameters to identify pathological parameter sets. ..."
  • Neocortex L5/6 pyramidal GLU cell Show Other
  • Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell Show Other
  • Neocortex V1 interneuron basket PV GABA cell Show Other
  • Neocortex fast spiking (FS) interneuron Show Other
  • Neocortex spiking regular (RS) neuron Show Other
  • Neocortex spiking low threshold (LTS) neuron Show Other
  • Neocortex layer 4 neuron Show Other
  • Neocortex layer 2-3 interneuron Show Other
  • Neocortex layer 4 interneuron Show Other
  • Neocortex layer 5 interneuron Show Other
  • Neocortex layer 6a interneuron Show Other
  • Neymotin SA, Dura-Bernal S, Lakatos P, Sanger TD, Lytton WW (2016) Show Other
dystdemo
  • Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org] Show Other
  • Dura-Bernal, Salvador [salvadordura at gmail.com] Show Other
I_KDr
Drug Discovery, Dystonia
False
True
Other categories referring to Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
Revisions: 14
Last Time: 6/26/2017 9:37:55 PM
Reviewer: System Administrator
Owner: Tom Morse - MoldelDB admin