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Data
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Concentration dependent nonlinear K+ and Cl- leak current (Huang et al. 2015)
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"In their seminal works on squid giant axons, Hodgkin, and Huxley
approximated the membrane leak current as Ohmic, i.e., linear, since
in their preparation, sub-threshold current rectification due to the
influence of ionic concentration is negligible.
Most studies on
mammalian neurons have made the same, largely untested,
assumption.
Here we show that the membrane time constant and input
resistance of mammalian neurons (when other major voltage-sensitive
and ligand-gated ionic currents are discounted) varies non-linearly
with membrane voltage, following the prediction of a
Goldman-Hodgkin-Katz-based passive membrane model.
..." (see paper for details and more).
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Huang S, Hong S, De Schutter E (2015) Show
Other
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Huang S, Hong S, De Schutter E (2015) Show
Other
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195569
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Huang, Shiwei [shiweihuang at outlook.com] Show
Other
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Hong, Sungho [shhong at oist.jp] Show
Other
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