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Data
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Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017)
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"Corticospinal neurons (SPI), thick-tufted pyramidal neurons in motor
cortex layer 5B that project caudally via the medullary pyramids,
display distinct class-specific electrophysiological properties in
vitro: strong sag with hyperpolarization, lack of adaptation, and a
nearly linear frequency-current (FI) relationship. We used our
electrophysiological data to produce a pair of large archives of SPI
neuron computer models in two model classes: 1. Detailed models with
full reconstruction; 2. Simplified models with 6 compartments. We
used a PRAXIS and an evolutionary multiobjective optimization (EMO) in
sequence to determine ion channel conductances.
..."
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Neocortex M1 L5B pyramidal pyramidal tract GLU cell Show
Other
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Neocortex primary motor area pyramidal layer 5 corticospinal cell Show
Other
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Neuron or other electrically excitable cell Show
Other
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Neymotin SA, Suter BA, Dura-Bernal S, Shepherd GM, Migliore M, Lytton WW (2017) Show
Other
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spidemo
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Corticospinal neuron
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Benjamin Suter, Ernie Forzano
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