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Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017)
spidemo_r5 [4764749]
"Corticospinal neurons (SPI), thick-tufted pyramidal neurons in motor cortex layer 5B that project caudally via the medullary pyramids, display distinct class-specific electrophysiological properties in vitro: strong sag with hyperpolarization, lack of adaptation, and a nearly linear frequency-current (FI) relationship. We used our electrophysiological data to produce a pair of large archives of SPI neuron computer models in two model classes: 1. Detailed models with full reconstruction; 2. Simplified models with 6 compartments. We used a PRAXIS and an evolutionary multiobjective optimization (EMO) in sequence to determine ion channel conductances. ..."
  • Neocortex M1 L5B pyramidal pyramidal tract GLU cell Show Other
  • Neocortex primary motor area pyramidal layer 5 corticospinal cell Show Other
  • Neuron or other electrically excitable cell Show Other
  • Neymotin SA, Suter BA, Dura-Bernal S, Shepherd GM, Migliore M, Lytton WW (2017) Show Other
spidemo
Corticospinal neuron
Benjamin Suter, Ernie Forzano
False
True
Other categories referring to Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017)
Revisions: 21
Last Time: 5/11/2018 2:08:26 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin