Computational model
Leech heart interneuron network model (Hill et al 2001, 2002)
HillEtAl2001_2 [1180164]
We have created a computational model of the timing network that paces the heartbeat of the medicinal leech, Hirudo medicinalis. In the intact nerve cord, segmental oscillators are mutually entrained to the same cycle period. Although experiments have shown that the segmental oscillators are coupled by inhibitory coordinating interneurons, the underlying mechanisms of intersegmental coordination have not yet been elucidated. To help understand this coordination, we have created a simple computational model with two variants: symmetric and asymmetric. See references for more details. Biologically realistic network models with two, six, and eight cells and a tutorial are available at the links to Calabrese's web site below.
  • Hill AA, Masino MA, Calabrese RL (2002) Show Other
  • Hill AA, Lu J, Masino MA, Olsen OH, Calabrese RL (2001) Show Other
  • Hill, Andrew A [aavhill at] Show Other
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Last Time: 2/26/2019 10:21:18 AM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin