|
|
|
Data
|
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
|
|
|
|
|
|
|
We developed a CA1
pyramidal cell model calibrated with a broad spectrum of in vitro data. Using simultaneous
dendritic and somatic recordings, and combining results for two different response measures
(peak vs. mean EPSP), two different stimulus formats (single shock vs. 50 Hz trains),
and two different spatial integration conditions (within vs. between-branch summation),
we found the cell's subthreshold responses to paired inputs are best described as a sum of
nonlinear subunit responses, where the subunits correspond to different dendritic branches.
In addition to suggesting a new type of experiment and providing testable predictions, our
model shows how conclusions regarding synaptic arithmetic can be influenced by an array
of seemingly innocuous experimental design choices.
|
-
Hippocampus CA1 pyramidal GLU cell Show
Other
|
|
|
|
|
|
|
-
Neuron or other electrically excitable cell Show
Other
|
|
|
|
|
-
Poirazi P, Brannon T, Mel BW (2003) Show
Other
-
Poirazi P, Brannon T, Mel BW (2003) Show
Other
-
Poirazi P, Brannon T, Mel BW (2003ab-sup) Show
Other
-
Polsky A, Mel BW, Schiller J (2004) Show
Other
|
|
|
CA1_multi
|
|
|
|
|
|
|
-
Poirazi, Panayiota [poirazi at imbb.forth.gr] Show
Other
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
167
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
