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A dendritic disinhibitory circuit mechanism for pathway-specific gating (Yang et al. 2016)
"While reading a book in a noisy café, how does your brain ‘gate in’ visual information while filtering out auditory stimuli? Here we propose a mechanism for such flexible routing of information flow in a complex brain network (pathway-specific gating), tested using a network model of pyramidal neurons and three classes of interneurons with connection probabilities constrained by data. We find that if inputs from different pathways cluster on a pyramidal neuron dendrite, a pathway can be gated-on by a disinhibitory circuit motif. ..."
  • Neocortex V1 L2/6 pyramidal intratelencephalic GLU cell Show Other
  • Yang GR, Murray JD, Wang XJ (2016) Show Other
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Revisions: 6
Last Time: 10/18/2018 5:08:40 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin