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Data
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A multilayer cortical model to study seizure propagation across microdomains (Basu et al. 2015)
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A realistic neural network was used to simulate a region of neocortex to obtain extracellular LFPs from ‘virtual micro-electrodes’ and produce test data for comparison with multisite microelectrode recordings. A model was implemented in the GENESIS neurosimulator. A simulated region of cortex was represented by layers 2/3, 5/6 (interneurons and pyramidal cells) and layer 4 stelate cells, spaced at 25 µm in each horizontal direction. Pyramidal cells received AMPA and NMDA inputs from neighboring cells at the basal and apical dendrites.
The LFP data was generated by simulating 16-site electrode array with the help of ‘efield’ objects arranged at the predetermined positions with respect to the surface of the simulated network. The LFP for the model is derived from a weighted average of the current sources summed over all cellular compartments. Cell models were taken from from Traub et al. (2005) J Neurophysiol 93(4):2194-232.
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Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell Show
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Neocortex U1 L5B pyramidal pyramidal tract GLU cell Show
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Thalamus reticular nucleus GABA cell Show
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Neocortex spiking low threshold (LTS) neuron Show
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Neocortex spiking regular (RS) neuron Show
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Neocortex layer 2-3 interneuron Show
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Neocortex layer 5 interneuron Show
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Basu I, Kudela P, Korzeniewska A, Franaszczuk PJ, Anderson WS (2015) Show
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Basu I, Kudela P, Anderson WS (2014) Show
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BasuEtAl2015
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Anderson WS, Kudela P
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