Computational model
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1_multi_r2 [622862]
In our experimental study, we combined paired patch-clamp recordings and two-photon Ca2+ imaging to quantify inhibition exerted by individual GABAergic contacts on hippocampal pyramidal cell dendrites. We observed that Ca2+ transients from back-propagating action potentials were significantly reduced during simultaneous activation of individual nearby GABAergic synapses. To simulate dendritic Ca2+ inhibition by individual GABAergic synapses, we employed a multi-compartmental CA1 pyramidal cell model with detailed morphology, voltage-gated channel distributions, and calcium dynamics, based with modifications on the model of Poirazi et al., 2003, modelDB accession # 20212.
  • Hippocampus CA1 pyramidal GLU cell Show Other
  • Neuron or other electrically excitable cell Show Other
  • Müllner FE, Wierenga CJ, Bonhoeffer T (2015) Show Other
  • Muellner, Fiona E [fiona.muellner at] Show Other
Other categories referring to CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
Revisions: 7
Last Time: 6/27/2017 10:19:10 AM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin