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Data
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Feedforward inhibition in pyramidal cells (Ferrante & Ascoli 2015)
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Michele Ferrante
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"Feedforward inhibition (FFI) enables pyramidal cells in area CA1 of the hippocampus
(CA1PCs) to remain easily excitable while faithfully representing a broad range of
excitatory inputs without quickly saturating. Despite the cortical ubiquity of FFI,
its specific function is not completely understood. FFI in CA1PCs is mediated by
two physiologically and morphologically distinct GABAergic interneurons: fast-spiking,
perisomatic-targeting basket cells and regular-spiking, dendritic-targeting bistratified
cells. These two FFI pathways might create layer-specific computational sub-domains
within the same CA1PC, but teasing apart their specific contributions remains
experimentally challenging. We implemented a biophysically realistic model of CA1PCs
using 40 digitally reconstructed morphologies and constraining synaptic numbers,
locations, amplitude, and kinetics with available experimental data. ..."
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Hippocampus CA1 pyramidal GLU cell Show
Other
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Neuron or other electrically excitable cell Show
Other
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FFI_CA1
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Ferrante, Michele [mferr133 at bu.edu] Show
Other
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michele.ferrante@nih.gov
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