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Regulation of motoneuron excitability by KCNQ/Kv7 modulators (Lombardo & Harrington 2016)
Joseph Lombardo
" ... Computer simulations confirmed that pharmacological enhancement of KCNQ/Kv7 channel (M current) activity decreases excitability and also suggested that the effects of inhibition of KCNQ/Kv7 channels on the excitability of spinal MNs do not depend on a direct effect in these neurons but likely on spinal cord synaptic partners. These results indicate that KCNQ/Kv7 channels have a fundamental role in the modulation of the excitability of spinal MNs acting both in these neurons and in their local presynaptic partners. ..."
  • Spinal cord lumbar motor neuron alpha ACh cell Show Other
  • Neuron or other electrically excitable cell Show Other
  • Lombardo J, Harrington MA (2016) Show Other
  • Lombardo, Joseph [josslomb at gmail.com] Show Other
josslomb@gmail.com
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Revisions: 12
Last Time: 12/15/2016 10:24:13 AM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin