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A model of cerebellar LTD including RKIP inactivation of Raf and MEK (Hepburn et al 2017)
Iain Hepburn
LTD_STEPS_2.1 [13070]
An updated stochastic model of cerebellar Long Term Depression (LTD) with improved realism. Dissociation of Raf kinase inhibitor protein (RKIP) from Mitogen-activated protein kinase kinase (MEK) and Raf kinase are added to an earlier published model. Calcium dynamics is updated as a constant-rate influx to more closely match experiment. AMPA receptor interactions are improved by adding phosphorylation and dephosphorylation of AMPA receptors when bound to glutamate receptor interacting protein (GRIP). The model is tuned to reproduce experimental calcium peak vs LTD amplitude curves accurately at 4 different calcium pulse durations.
  • Hepburn I, Jain A, Gangal H, Yamamoto Y, Tanaka-Yamamoto K, De Schutter E (2017) Show Other
  • Hepburn, Iain [ihepburn at oist.jp] Show Other
  • Jain, Anant [anantdavinci at gmail.com] Show Other
  • Gangal, Himanshu [himanshugangal at gmail.com] Show Other
ihepburn@oist.jp
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Revisions: 10
Last Time: 1/26/2017 10:32:30 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin