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Data
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Species-specific wiring for direction selectivity in the mammalian retina (Ding et al 2016)
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" ... Here we present a detailed connectomic reconstruction
of SAC circuitry in mouse retina and describe two previously unknown features of synapse distributions along SAC
dendrites: input and output synapses are segregated, with inputs restricted to proximal dendrites; and the distribution
of inhibitory inputs is fundamentally different from that observed in rabbit retina. An anatomically constrained SAC
network model suggests that SAC–SAC wiring differences between mouse and rabbit retina underlie distinct contributions
of synaptic inhibition to velocity and contrast tuning and receptive field structure. In particular, the model indicates
that mouse connectivity enables SACs to encode lower linear velocities that account for smaller eye diameter, thereby
conserving angular velocity tuning. These predictions are confirmed with calcium imaging of mouse SAC dendrites
responding to directional stimuli. ..."
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Ding H, Smith RG, Poleg-Polsky A, Diamond JS, Briggman KL (2016) Show
Other
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tom.morse@yale.edu
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starburst amacrine
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