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Data
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Model for K-ATP mediated bursting in mSNc DA neurons (Knowlton et al 2018)
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Christopher Knowlton
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"Burst firing in medial substantia nigra dopamine (mSN DA) neurons has been selectively linked to novelty-induced exploration behavior in mice. Burst firing in mSN DA neurons, in contrast to lateral SN DA neurons, requires functional ATP-sensitive potassium channels (K-ATP) both in vitro and in vivo. However, the precise role of K-ATP channels in promoting burst firing is un-known. We show experimentally that L-type calcium channel activity in mSN DA neurons en-hances open probability of K-ATP channels. We then generated a mathematical model to study the role of Ca2+ dynamics driving K-ATP channel function in mSN DA neurons during bursting. ..."
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Substantia nigra pars compacta DA cell Show
Other
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Neuron or other electrically excitable cell Show
Other
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Knowlton C, Kutterer S, Roeper J, Canavier CC (2018) Show
Other
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RELEASE
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cknow1@lsuhsc.edu
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Christopher Knowlton
Carmen Canavier
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