|
|
|
Data
|
Gap junction plasticity as a mechanism to regulate network-wide oscillations (Pernelle et al 2018)
|
Guillaume Pernelle
|
|
|
|
|
"Oscillations of neural activity emerge when many neurons repeatedly activate together and are observed in many brain regions, particularly during sleep and attention. Their functional role is still debated, but could be associated with normal cognitive processes such as memory formation or with pathologies such as schizophrenia and autism. Powerful oscillations are also a hallmark of epileptic seizures. Therefore, we wondered what mechanism could regulate oscillations. A type of neuronal coupling, called gap junctions, has been shown to promote synchronization between inhibitory neurons. Computational models show that when gap junctions are strong, neurons synchronize together. Moreover recent investigations show that the gap junction coupling strength is not static but plastic and dependent on the firing properties of the neurons. Thus, we developed a model of gap junction plasticity in a network of inhibitory and excitatory neurons. We show that gap junction plasticity can maintain the right amount of oscillations to prevent pathologies from emerging. Finally, we show that gap junction plasticity serves an additional functional role and allows for efficient and robust information transfer."
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
-
Pernelle G, Nicola W, Clopath C (2018) Show
Other
|
|
|
|
|
|
|
|
|
|
-
Pernelle, Guillaume [g.pernelle14 at imperial.ac.uk] Show
Other
|
g.pernelle14@imperial.ac.uk
|
|
|
|
|
|
|
|
|
|
|
|
|
Gap junction plasticity
|
|
|
Guillaume Pernelle [g.pernelle14 at imperial.ac.uk]
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
