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Cortical Layer 5b pyr. cell with [Na+]i mechanisms, from Hay et al 2011 (Zylbertal et al 2017)
Asaph Zylbertal
" ... Based on a large body of experimental recordings from both the soma and dendrites of L5b pyramidal cells in adult rats, we characterized key features of the somatic and dendritic firing and quantified their statistics. We used these features to constrain the density of a set of ion channels over the soma and dendritic surface via multi-objective optimization with an evolutionary algorithm, thus generating a set of detailed conductance-based models that faithfully replicate the back-propagating action potential activated Ca(2+) spike firing and the perisomatic firing response to current steps, as well as the experimental variability of the properties. Furthermore, we show a useful way to analyze model parameters with our sets of models, which enabled us to identify some of the mechanisms responsible for the dynamic properties of L5b pyramidal cells as well as mechanisms that are sensitive to morphological changes. ..."
  • Neuron or other electrically excitable cell Show Other
  • Hay E, Hill S, Schürmann F, Markram H, Segev I (2011) Show Other
  • Zylbertal A, Yarom Y, Wagner S (2017) Show Other
  • Zylbertal, Asaph [asaph.zylbertal at mail.huji.ac.il] Show Other
asaph.zylbertal@mail.huji.ac.il
Layer 5b pyramidal cell
Intracellular Sodium
Hay, E., Hill, S., Schürmann, F., Markram, H., and Segev, I. (2011). Models of Neocortical Layer 5b Pyramidal Cells Capturing a Wide Range of Dendritic and Perisomatic Active Properties. PLoS Comput. Biol. 7, e1002107. doi:10.1371/journal.pcbi.1002107.
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Other categories referring to Cortical Layer 5b pyr. cell with [Na+]i mechanisms, from Hay et al 2011 (Zylbertal et al 2017)
Revisions: 6
Last Time: 10/17/2018 4:21:12 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Asaph Zylbertal