Computational model
Orientation preference in L23 V1 pyramidal neurons (Park et al 2019)
Athanasia Papoutsi
"Pyramidal neurons integrate synaptic inputs from basal and apical dendrites to generate stimulus-specific responses. It has been proposed that feed-forward inputs to basal dendrites drive a neuron’s stimulus preference, while feedback inputs to apical dendrites sharpen selectivity. However, how a neuron’s dendritic domains relate to its functional selectivity has not been demonstrated experimentally. We performed 2-photon dendritic micro-dissection on layer-2/3 pyramidal neurons in mouse primary visual cortex. We found that removing the apical dendritic tuft did not alter orientation-tuning. Furthermore, orientation-tuning curves were remarkably robust to the removal of basal dendrites: ablation of 2 basal dendrites was needed to cause a small shift in orientation preference, without significantly altering tuning width. Computational modeling corroborated our results and put limits on how orientation preferences among basal dendrites differ in order to reproduce the post-ablation data. In conclusion, neuronal orientation-tuning appears remarkably robust to loss of dendritic input."
  • Neocortex L2/3 pyramidal GLU cell Show Other
  • Park J, Papoutsi A, Ash RT, Marin MA, Poirazi P, Smirnakis SM (2019) Show Other
  • Papoutsi, Athanasia [athpapoutsi at] Show Other
Neocortex V1 L23 pyramidal neuron
Other categories referring to Orientation preference in L23 V1 pyramidal neurons (Park et al 2019)
Revisions: 9
Last Time: 12/2/2019 2:19:11 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin