SenseLab
Computational model
  Data
Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
Fleur Zeldenrust
TCR_r3 [38781776]
Mammalian thalamocortical relay (TCR) neurons switch their firing activity between a tonic spiking and a bursting regime. In a combined experimental and computational study, we investigated the features in the input signal that single spikes and bursts in the output spike train represent and how this code is influenced by the membrane voltage state of the neuron. Identical frozen Gaussian noise current traces were injected into TCR neurons in rat brain slices to adjust, fine-tune and validate a three-compartment TCR model cell (Destexhe et al. 1998, accession number 279). Three currents were added: an h-current (Destexhe et al. 1993,1996, accession number 3343), a high-threshold calcium current and a calcium- activated potassium current (Huguenard & McCormick 1994, accession number 3808). The information content carried by the various types of events in the signal as well as by the whole signal was calculated. Bursts phase-lock to and transfer information at lower frequencies than single spikes. On depolarization the neuron transits smoothly from the predominantly bursting regime to a spiking regime, in which it is more sensitive to high-frequency fluctuations. Finally, the model was used to in the more realistic “high-conductance state” (Destexhe et al. 2001, accession number 8115), while being stimulated with a Poisson input (Brette et al. 2007, Vogels & Abbott 2005, accession number 83319), where fluctuations are caused by (synaptic) conductance changes instead of current injection. Under “standard” conditions bursts are difficult to initiate, given the high degree of inactivation of the T-type calcium current. Strong and/or precisely timed inhibitory currents were able to remove this inactivation.
  • Thalamus geniculate nucleus/lateral principal GLU cell Show Other
  • Neuron or other electrically excitable cell Show Other
  • Zeldenrust F, Chameau P, Wadman WJ (2018) Show Other
  • Destexhe A, Bal T, McCormick DA, Sejnowski TJ (1996) Show Other
  • Huguenard JP, Mccormick DA (1994) Show Other
  • Destexhe A, Rudolph M, Fellous JM, Sejnowski TJ (2001) Show Other
  • Brette R, Rudolph M, Carnevale T, Hines M, Beeman D, Bower JM, Diesmann M, Morrison A, Goodman PH, Harris FC, Zirpe M, Natschläger T, Pecevski D, Ermentrout B, Djurfeldt M, Lansner A, Rochel O, Vieville T, Muller E, Davison AP, El Boustani S, Destexhe A (2007) Show Other
  • Vogels TP, Abbott LF (2005) Show Other
  • Destexhe A, Neubig M, Ulrich D, Huguenard J (1998) Show Other
  • Destexhe A, Babloyantz A, Sejnowski TJ (1993) Show Other
TCR
  • Zeldenrust, Fleur [fleurzeldenrust at gmail.com] Show Other
F.Zeldenrust@neurophysiology.nl
Zeldenrust, F., Chameau, P., & Wadman, W. J. Spike and Burst Coding in Thalamocortical Relay Cells. Under review at PLoS Computational Biology.
False
False
Other categories referring to Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
Revisions: 21
Last Time: 3/14/2018 11:06:36 AM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin