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A mathematical model of a neurovascular unit (Dormanns et al 2015, 2016) (Farrs & David 2011)
Allanah Kenny
NVU12Model.zip [20075]
Here a lumped parameter numerical model of a neurovascular unit is presented, representing an intercellular communication system based on ion exchange through pumps and channels between neurons, astrocytes, smooth muscle cells, endothelial cells, and the spaces between these cells: the synaptic cleft between the neuron and astrocyte, the perivascular space between the astrocyte and SMC, and the extracellular space surrounding the cells. The model contains various cellular and chemical pathways such as potassium, astrocytic calcium, and nitric oxide. The model is able to simulate neurovascular coupling, the process characterised by an increase in neuronal activity followed by a rapid dilation of local blood vessels and hence increased blood supply providing oxygen and glucose to cells in need.
  • Farr H, David T (2011) Show Other
  • Dormanns K, van Disseldorp EM, Brown RG, David T (2015) Show Other
  • Dormanns K, Brown RG, David T (2016) Show Other
allanah.kenny@pg.canterbury.ac.nz
Allanah Kenny Tim David
21781976 25167790 26796228
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Revisions: 3
Last Time: 9/29/2017 10:57:36 AM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin