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Sequential neuromodulation of Hebbian plasticity in reward-based navigation (Brzosko et al 2017)
Sara Znnone
" ...Here, we demonstrate that sequential neuromodulation of STDP by acetylcholine and dopamine offers an efficacious model of reward-based navigation. Specifically, our experimental data in mouse hippocampal slices show that acetylcholine biases STDP toward synaptic depression, whilst subsequent application of dopamine converts this depression into potentiation. Incorporating this bidirectional neuromodulation-enabled correlational synaptic learning rule into a computational model yields effective navigation toward changing reward locations, as in natural foraging behavior. ..."
  • Brzosko Z, Zannone S, Schultz W, Clopath C, Paulsen O (2017) Show Other
  • Zannone, Sara [s.zannone14 at imperial.ac.uk] Show Other
s.zannone14@imperial.ac.uk
Abstract Spike Response Model0
Sara Zannone (s.zannone14@imperial.ac.uk)
Brzosko Z, Zannone S, Schultz W, Clopath C, Paulsen O. Sequential neuromodulation of Hebbian plasticity offers mechanism for effective reward-based navigation. eLife. 2017;6.
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Revisions: 7
Last Time: 10/4/2017 1:26:07 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin