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Data
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Knox implementation of Destexhe 1998 spike and wave oscillation model (Knox et al 2018)
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Andrew Knox
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" ...The aim of this study was to use an established thalamocortical computer model to determine how T-type calcium channels work in concert with cortical excitability to contribute to pathogenesis and treatment response in CAE.
METHODS:
The model is comprised of cortical pyramidal, cortical inhibitory, thalamocortical relay, and thalamic reticular single-compartment neurons, implemented with Hodgkin-Huxley model ion channels and connected by AMPA, GABAA , and GABAB synapses. Network behavior was simulated for different combinations of T-type calcium channel conductance, inactivation time, steady state activation/inactivation shift, and cortical GABAA conductance.
RESULTS:
Decreasing cortical GABAA conductance and increasing T-type calcium channel conductance converted spindle to spike and wave oscillations; smaller changes were required if both were changed in concert. In contrast, left shift of steady state voltage activation/inactivation did not lead to spike and wave oscillations, whereas right shift reduced network propensity for oscillations of any type...."
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Thalamus reticular nucleus GABA cell Show
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Thalamus geniculate nucleus/lateral principal GLU cell Show
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Knox AT, Glauser T, Tenney J, Lytton WW, Holland K (2018) Show
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Knox, Andrew [knox at neurology.wisc.edu] Show
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Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr] Show
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Knox@neurology.wisc.edu
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