Computational model
Knox implementation of Destexhe 1998 spike and wave oscillation model (Knox et al 2018)
Andrew Knox
KnoxEtAl2017 [1474498]
" ...The aim of this study was to use an established thalamocortical computer model to determine how T-type calcium channels work in concert with cortical excitability to contribute to pathogenesis and treatment response in CAE. METHODS: The model is comprised of cortical pyramidal, cortical inhibitory, thalamocortical relay, and thalamic reticular single-compartment neurons, implemented with Hodgkin-Huxley model ion channels and connected by AMPA, GABAA , and GABAB synapses. Network behavior was simulated for different combinations of T-type calcium channel conductance, inactivation time, steady state activation/inactivation shift, and cortical GABAA conductance. RESULTS: Decreasing cortical GABAA conductance and increasing T-type calcium channel conductance converted spindle to spike and wave oscillations; smaller changes were required if both were changed in concert. In contrast, left shift of steady state voltage activation/inactivation did not lead to spike and wave oscillations, whereas right shift reduced network propensity for oscillations of any type...."
  • Thalamus reticular nucleus GABA cell Show Other
  • Thalamus geniculate nucleus/lateral principal GLU cell Show Other
  • Knox AT, Glauser T, Tenney J, Lytton WW, Holland K (2018) Show Other
  • Knox, Andrew [knox at] Show Other
  • Destexhe, Alain [Destexhe at] Show Other
Other categories referring to Knox implementation of Destexhe 1998 spike and wave oscillation model (Knox et al 2018)
Revisions: 12
Last Time: 1/29/2018 8:01:31 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin