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Data
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Paradoxical effect of fAHP amplitude on gain in dentate gyrus granule cells (Jaffe & Brenner 2018)
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David B. Jaffe
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The afterhyperpolarization (AHP) is canonically viewed as a major factor underlying the
refractory period, serving to limit neuronal firing rate. We recently reported (Wang et al,
J. Neurophys. 116:456, 2016) that enhancing the amplitude of the fast AHP in
a relatively slowly firing neuron (versus fast spiking neurons), augments neuronal excitability
in dentate gyrus granule neurons expressing gain-of-function BK channels. Here we present a novel,
quantitative hypothesis for how varying the amplitude of the fast AHP (fAHP) can, paradoxically,
influence a subsequent spike tens of milliseconds later.
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Jaffe, David B [david.jaffe at utsa.edu] Show
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david.jaffe@utsa.edu
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A computational model for how the fast afterhyperpolarization paradoxically increases gain in regularly firing neurons, J. Neurophysiology (under review)
D.B Jaffe, D.B.* and Brenner R.**
*Department of Biology, UTSA Neurosciences Institute, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA.
**Department of Cell and Integrative Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
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