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Data
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Role of the AIS in the control of spontaneous frequency of dopaminergic neurons (Meza et al 2017)
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Luciana Francisca Lopez Jury
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Computational modeling showed that the
size of the Axon Initial Segment (AIS), but not its position within the somatodendritic domain, is the major causal determinant of the tonic firing rate in the intact model, by virtue of the higher intrinsic frequency of the isolated AIS. Further mechanistic analysis of the relationship between neuronal morphology and firing rate showed that dopaminergic neurons function as a coupled oscillator whose frequency of discharge results from a compromise between AIS and somatodendritic oscillators.
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Substantia nigra pars compacta DA cell Show
Other
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Neuron or other electrically excitable cell Show
Other
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Meza RC, López-Jury L, Canavier CC, Henny P (2018) Show
Other
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lucianalopezjury@gmail.com
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Luciana Lopez-Jury
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J. Neurosci ; 10.1523/JNEUROSCI.1432-17.2017
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