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Data
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The origin of different spike and wave-like events (Hall et al 2017)
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Roger Truab
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Acute In vitro models have revealed a great deal of information about
mechanisms underlying many types of epileptiform activity. However,
few examples exist that shed light on spike and wave (SpW) patterns of
pathological activity. SpW are seen in many epilepsy syndromes, both
generalised and focal, and manifest across the entire age
spectrum. They are heterogeneous in terms of their severity, symptom
burden and apparent anatomical origin (thalamic, neocortical or both),
but any relationship between this heterogeneity and underlying
pathology remains elusive. Here we demonstrate that physiological
delta frequency rhythms act as an effective substrate to permit
modelling of SpW of cortical origin and may help to address this
issue.
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Thalamus geniculate nucleus/lateral principal GLU cell Show
Other
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Thalamus reticular nucleus GABA cell Show
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Neocortex U1 L6 pyramidal corticalthalamic GLU cell Show
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Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell Show
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Neocortex fast spiking (FS) interneuron Show
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Neocortex spiking regular (RS) neuron Show
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Neocortex spiking low threshold (LTS) neuron Show
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Hall SP, Traub RD, Adams NE, Cunningham MO, Schofield I, Jenkins AJ, Whittington MA (2018) Show
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Traub, Roger D [rtraub at us.ibm.com] Show
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tom.morse@yale.edu
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