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The origin of different spike and wave-like events (Hall et al 2017)
Roger Truab
HallEtAl2017.zip [1137709]
Acute In vitro models have revealed a great deal of information about mechanisms underlying many types of epileptiform activity. However, few examples exist that shed light on spike and wave (SpW) patterns of pathological activity. SpW are seen in many epilepsy syndromes, both generalised and focal, and manifest across the entire age spectrum. They are heterogeneous in terms of their severity, symptom burden and apparent anatomical origin (thalamic, neocortical or both), but any relationship between this heterogeneity and underlying pathology remains elusive. Here we demonstrate that physiological delta frequency rhythms act as an effective substrate to permit modelling of SpW of cortical origin and may help to address this issue. ..."
  • Thalamus geniculate nucleus/lateral principal GLU cell Show Other
  • Thalamus reticular nucleus GABA cell Show Other
  • Neocortex U1 L6 pyramidal corticalthalamic GLU cell Show Other
  • Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell Show Other
  • Neocortex fast spiking (FS) interneuron Show Other
  • Neocortex spiking regular (RS) neuron Show Other
  • Neocortex spiking low threshold (LTS) neuron Show Other
  • Hall SP, Traub RD, Adams NE, Cunningham MO, Schofield I, Jenkins AJ, Whittington MA (2018) Show Other
tom.morse@yale.edu
Hall et al 2017
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Revisions: 2
Last Time: 12/13/2017 11:09:57 AM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin