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Data
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Cortical oscillations and the basal ganglia (Fountas & Shanahan 2017)
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Tom Morse - MoldelDB admin
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"Although brain oscillations involving the basal ganglia (BG) have been
the target of extensive research, the main focus lies
disproportionally on oscillations generated within the BG circuit
rather than other sources, such as cortical areas. We remedy this here
by investigating the influence of various cortical frequency bands on
the intrinsic effective connectivity of the BG, as well as the role of
the latter in regulating cortical behaviour. To do this, we construct
a detailed neural model of the complete BG circuit based on fine-tuned
spiking neurons, with both electrical and chemical synapses as well as
short-term plasticity between structures. As a measure of effective
connectivity, we estimate information transfer between nuclei by means
of transfer entropy. Our model successfully reproduces firing and
oscillatory behaviour found in both the healthy and Parkinsonian
BG. We found that, indeed, effective connectivity changes dramatically
for different cortical frequency bands and phase offsets, which are
able to modulate (or even block) information flow in the three major
BG pathways. ..."
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Subthalamic nucleus principal GABA cell Show
Other
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Globus pallidus principal GABA cell Show
Other
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Substantia nigra pars reticulata principal GABA cell Show
Other
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Fountas, Zafeirios [zfountas at imperial.ac.uk] Show
Other
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tom.morse@yale.edu
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