Computational model
Cortical oscillations and the basal ganglia (Fountas & Shanahan 2017)
Tom Morse - MoldelDB admin
"Although brain oscillations involving the basal ganglia (BG) have been the target of extensive research, the main focus lies disproportionally on oscillations generated within the BG circuit rather than other sources, such as cortical areas. We remedy this here by investigating the influence of various cortical frequency bands on the intrinsic effective connectivity of the BG, as well as the role of the latter in regulating cortical behaviour. To do this, we construct a detailed neural model of the complete BG circuit based on fine-tuned spiking neurons, with both electrical and chemical synapses as well as short-term plasticity between structures. As a measure of effective connectivity, we estimate information transfer between nuclei by means of transfer entropy. Our model successfully reproduces firing and oscillatory behaviour found in both the healthy and Parkinsonian BG. We found that, indeed, effective connectivity changes dramatically for different cortical frequency bands and phase offsets, which are able to modulate (or even block) information flow in the three major BG pathways. ..."
  • Subthalamic nucleus principal GABA cell Show Other
  • Globus pallidus principal GABA cell Show Other
  • Substantia nigra pars reticulata principal GABA cell Show Other
  • Fountas, Zafeirios [zfountas at] Show Other
Other categories referring to Cortical oscillations and the basal ganglia (Fountas & Shanahan 2017)
Revisions: 4
Last Time: 1/3/2018 5:05:23 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin