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Data
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A systems model of Parkinson’s disease using biochemical systems theory (Sasidharakurup et al. 2017)
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Shyam Diwakar
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Major pathways involving in Parkinson's disease (PD) such as alphasynuclein aggregation, dopamine
synthesis, lewy body formation, tau phosphorylation, parkin, and apoptosis were modeled
using stochastic differential equations. Pathways were modeled and simulated using the
biochemical pathway visualization program CellDesigner, a modeling tool for gene-regulatory
and biochemical networks that support graphical notation and listing of symbols. The model allows
a qualitative analysis of PD and a key signalling pathways for evaluating PD treatment conditions
relating pathophysiology to molecular concentration changes recorded in experiments.
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Sasidharakurup H, Melethadathil N, Nair B, Diwakar S (2017) Show
Other
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Sasidharakurup, Hemalatha [hemalathas at am.amrita.edu] Show
Other
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Diwakar, Shyam [shyam at amrita.edu] Show
Other
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shyam@amrita.edu
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Biochemical SystemsTheory
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Cell Designer
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Sasidharakurup, Hemalatha [hemalathas@am.amrita.edu]
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