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A model of neurovascular coupling and the BOLD response (Mathias et al 2017, Kenny et al 2018)
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Allanah Kenny
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Here a lumped parameter numerical model of a neurovascular unit is presented, representing an intercellular communication system based on ion exchange through pumps and channels between neurons, astrocytes, smooth muscle cells, endothelial cells, and the spaces between these cells: the synaptic cleft between the neuron and astrocyte, the perivascular space between the astrocyte and SMC, and the extracellular space surrounding the cells.
The model contains various cellular and chemical pathways such as potassium, astrocytic calcium, and nitric oxide.
The model is able to simulate neurovascular coupling, the process characterised by an increase in neuronal activity followed by a rapid dilation of local blood vessels and hence increased blood supply providing oxygen and glucose to cells in need.
The model also incorporates the BOLD response.
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Mathias EJ, Plank MJ, David T (2017) Show
Other
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Kenny A, Plank MJ, David T (2018) Show
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Dormanns K, Brown RG, David T (2016) Show
Other
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Dormanns K, van Disseldorp EM, Brown RG, David T (2015) Show
Other
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Farr H, David T (2011) Show
Other
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allanah.kenny@pg.canterbury.ac.nz
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Kenny, A., Plank, M. J., & David, T. (2018). The role of astrocytic calcium and TRPV4 channels in neurovascular coupling. Journal of Computational Neuroscience, 44(1), 97–114. http://doi.org/10.1007/s10827-017-0671-7
Mathias, E. J., Plank, M. J., & David, T. (2017). A model of neurovascular coupling and the BOLD response: PART I. Computer Methods in Biomechanics and Biomedical Engineering, 20(5), 508–518. http://doi.org/10.1080/10255842.2016.1255732
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