BrainPharm: Computational model - Striatal D1R medium spiny neuron, including a subcellular DA cascade (Lindroos et al 2018)

Computational model

Data

Name

Striatal D1R medium spiny neuron, including a subcellular DA cascade (Lindroos et al 2018)

Submitter name

Robert Lindroos

Pipeline ID

Model File

Beskow [5050682]

Notes

We are investigating how dopaminergic modulation of single channels can be combined to make the D1R possitive MSN more excitable. We also connect multiple channels to substrates of a dopamine induced subcellular cascade to highlight that the classical pathway is too slow to explain DA induced kinetics in the subsecond range (Howe and Dombeck, 2016. doi: 10.1038/nature18942)

Model Neurons

Neostriatum medium spiny direct pathway GABA cell Show Other

More Cells

Neostriatum spiny neuron Show Other

Model Currents

I A Show Other
I A, slow Show Other
I Calcium Show Other
I CAN Show Other
I K Show Other
I K,Ca Show Other
I K,leak Show Other
I Krp Show Other
I Na,t Show Other
I Potassium Show Other
I R Show Other
I T low threshold Show Other
Kir Show Other

Model Receptors

D1 Show Other
Dopaminergic Receptor Show Other
AMPA Show Other
Gaba Show Other
NMDA Show Other

Model Type

Axon Show Other
Channel/Receptor Show Other
Dendrite Show Other
Molecular Network Show Other
Synapse Show Other
Neuron or other electrically excitable cell Show Other

Model Concept

Action Potentials Show Other
Detailed Neuronal Models Show Other
Electrical-chemical Show Other
G-protein coupled Show Other
Membrane Properties Show Other
Neuromodulation Show Other
Multiscale Show Other
Synaptic noise Show Other

Simulator software

NEURON Show Other
Python Show Other

Model papers

Lindroos R, Dorst MC, Du K, Filipovic M, Keller D, Ketzef M, Kozlov AK, Kumar A, Lindahl M, Nair AG, Pérez-Fernández J, Grillner S, Silberberg G, Hellgren Kotaleski J (2018) Show Other

Gene

hg folder name (applicable when in ModelDB hg)

Beskow

Region Organism

Basal ganglia Show Other
Striatum Show Other

Model ID Number

Gap Junctions

Implemented by

Lindroos, Robert [robert.lindroos at ki.se] Show Other
Du, Kai [kai.du at ki.se] Show Other
Keller, Daniel Show Other
Kozlov, Alexander [akozlov at nada.kth.se] Show Other

Public Submitter Email Address

robert.lindroos@ki.se

Other Neuron

Model Neurotransmitters

Dopamine Show Other
Gaba Show Other
Glutamate Show Other

Other Receptor

Other Current

Other Neurotransmitter

Other Model Type

Other Concept

Other Simulator

Other Implementer

Lindroos, Robert [robert.lindroos at ki.se]

Alternative Version

Citation

doi: 10.3389/fncir.2018.00003

Default File Notes

Other Gene

Simulation Platform ID

Has Model View

False

Component

RAM

Hide Auto-launch button

True

Run Protocols

ICG Channel Details

ICG Detail_237653 Show Other
ICG Detail_237653 Show Other
ICG Detail_237653 Show Other
ICG Detail_237653 Show Other
ICG Detail_237653 Show Other
ICG Detail_237653 Show Other
ICG Detail_237653 Show Other
ICG Detail_237653 Show Other
ICG Detail_237653 Show Other
ICG Detail_237653 Show Other
ICG Detail_237653 Show Other
ICG Detail_237653 Show Other
ICG Detail_237653 Show Other
ICG Detail_237653 Show Other
ICG Detail_237653 Show Other
ICG Detail_237653 Show Other

Species

Other categories referring to Striatal D1R medium spiny neuron, including a subcellular DA cascade (Lindroos et al 2018)

Revisions:	15
Last Time:	2/10/2023 10:54:25 AM
Reviewer:	Rui Li
Owner:	Tom Morse - MoldelDB admin