SenseLab
Computational model
  Data
Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
Pipeline user 340
"The dendritic processing in cerebellar Purkinje cells (PCs), which integrate synaptic inputs coming from hundreds of thousands granule cells and molecular layer interneurons, is still unclear. Here we have tested a leading hypothesis maintaining that the significant PC output code is represented by burst-pause responses (BPRs), by simulating PC responses in a biophysically detailed model that allowed to systematically explore a broad range of input patterns. BPRs were generated by input bursts and were more prominent in Zebrin positive than Zebrin negative (Z+ and Z-) PCs. Different combinations of parallel fiber and molecular layer interneuron synapses explained type I, II and III responses observed in vivo. BPRs were generated intrinsically by Ca-dependent K channel activation in the somato-dendritic compartment and the pause was reinforced by molecular layer interneuron inhibition. BPRs faithfully reported the duration and intensity of synaptic inputs, such that synaptic conductance tuned the number of spikes and release probability tuned their regularity in the millisecond range. ..."
Purkinjecell_2017
  • Masoli, Stefano [stefano.masoli at unipv.it] Show Other
tom.morse@yale.edu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602117/
False
False
Other categories referring to Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
Revisions: 13
Last Time: 4/20/2020 7:49:11 AM
Reviewer: Tom Morse - MoldelDB admin
Owner: Bulletin Board System