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Signaling pathways In D1R containing striatal spiny projection neurons (Blackwell et al 2018)
Kim Blackwell
We implemented a mechanistic model of signaling pathways activated by dopamine D1 receptors, acetylcholine receptors, and glutamate. We use our novel, computationally efficient simulator, NeuroRD, to simulate stochastic interactions both within and between dendritic spines. Results show that the combined activity of several key plasticity molecules correctly predicts the occurrence of either LTP, LTD or no plasticity for numerous experimental protocols.
  • Neostriatum medium spiny direct pathway GABA cell Show Other
  • Blackwell KT, Salinas AG, Tewatia P, English B, Hellgren Kotaleski J, Lovinger DM (2019) Show Other
D1signal_modelDB
  • Blackwell, Avrama [avrama at gmu.edu] Show Other
kblackw1@gmu.edu
NeuroRD
Molecular Mechanisms Underlying Striatal Synaptic Plasticity: Relevance to Chronic Alcohol Consumption and Seeking. Eur J Neurosci. 2018 PMID: 29602186
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Revisions: 14
Last Time: 11/20/2018 2:28:03 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin