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Signaling pathways In D1R containing striatal spiny projection neurons (Blackwell et al 2018)
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Kim Blackwell
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We implemented a mechanistic model of signaling pathways activated by dopamine D1 receptors, acetylcholine receptors, and glutamate. We use our novel, computationally efficient simulator, NeuroRD, to simulate stochastic interactions both within and between dendritic spines. Results show that the combined activity of several key plasticity molecules correctly predicts the occurrence of either LTP, LTD or no plasticity for numerous experimental protocols.
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Neostriatum medium spiny direct pathway GABA cell Show
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Blackwell KT, Salinas AG, Tewatia P, English B, Hellgren Kotaleski J, Lovinger DM (2019) Show
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D1signal_modelDB
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Blackwell, Avrama [avrama at gmu.edu] Show
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kblackw1@gmu.edu
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Molecular Mechanisms Underlying Striatal Synaptic Plasticity: Relevance to Chronic Alcohol Consumption and Seeking. Eur J Neurosci. 2018 PMID: 29602186
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