BrainPharm: Computational model - Signaling pathways In D1R containing striatal spiny projection neurons (Blackwell et al 2018)

Computational model

Data

Name

Signaling pathways In D1R containing striatal spiny projection neurons (Blackwell et al 2018)

Submitter name

Kim Blackwell

Pipeline ID

Model File

D1signal_modelDB_r3 [1220214]

Notes

We implemented a mechanistic model of signaling pathways activated by dopamine D1 receptors, acetylcholine receptors, and glutamate. We use our novel, computationally efficient simulator, NeuroRD, to simulate stochastic interactions both within and between dendritic spines. Results show that the combined activity of several key plasticity molecules correctly predicts the occurrence of either LTP, LTD or no plasticity for numerous experimental protocols.

Model Neurons

Neostriatum medium spiny direct pathway GABA cell Show Other

More Cells

Model Currents

Model Receptors

D1 Show Other
mGluR5 Show Other
M1 Show Other
M4 Show Other

Model Type

Molecular Network Show Other
Synapse Show Other

Model Concept

G-protein coupled Show Other
Long-term Synaptic Plasticity Show Other
Signaling pathways Show Other
Alcohol Use Disorder Show Other

Simulator software

NeuroRD Show Other

Model papers

Blackwell KT, Salinas AG, Tewatia P, English B, Hellgren Kotaleski J, Lovinger DM (2019) Show Other

Gene

hg folder name (applicable when in ModelDB hg)

D1signal_modelDB

Region Organism

Basal ganglia Show Other
Striatum Show Other

Model ID Number

Gap Junctions

Implemented by

Blackwell, Avrama [avrama at gmu.edu] Show Other

Public Submitter Email Address

kblackw1@gmu.edu

Other Neuron

Model Neurotransmitters

Acetylcholine Show Other
Dopamine Show Other
Endocannabinoid Show Other
Glutamate Show Other

Other Receptor

Other Current

Other Neurotransmitter

Other Model Type

Other Concept

Other Simulator

NeuroRD

Other Implementer

Alternative Version

Citation

Molecular Mechanisms Underlying Striatal Synaptic Plasticity: Relevance to Chronic Alcohol Consumption and Seeking. Eur J Neurosci. 2018 PMID: 29602186

Default File Notes

Other Gene

Simulation Platform ID

Has Model View

False

Component

RAM

Hide Auto-launch button

False

Run Protocols

ICG Channel Details

Species

Other categories referring to Signaling pathways In D1R containing striatal spiny projection neurons (Blackwell et al 2018)

Run Curation.Model in ModelDB (1)

Revisions:	14
Last Time:	11/20/2018 2:28:03 PM
Reviewer:	Tom Morse - MoldelDB admin
Owner:	Tom Morse - MoldelDB admin