BrainPharm: Computational model - CA1 pyramidal neuron: Persistent Na current mediates steep synaptic amplification (Hsu et al 2018)

Computational model

Data

Name

CA1 pyramidal neuron: Persistent Na current mediates steep synaptic amplification (Hsu et al 2018)

Submitter name

Ching-Lung Hsu

Pipeline ID

Model File

HsuEtAl2018_r1 [3548687]

Notes

This paper shows that persistent sodium current critically contributes to the subthreshold nonlinear dynamics of CA1 pyramidal neurons and promotes rapidly reversible conversion between place-cell and silent-cell in the hippocampus. A simple model built with realistic axo-somatic voltage-gated sodium channels in CA1 (Carter et al., 2012; Neuron 75, 1081–1093) demonstrates that the biophysics of persistent sodium current is sufficient to explain the synaptic amplification effects. A full model built previously (Grienberger et al., 2017; Nature Neuroscience, 20(3): 417–426) with detailed morphology, ion channel types and biophysical properties of CA1 place cells naturally reproduces the steep voltage dependence of synaptic responses.

Model Neurons

Hippocampus CA1 pyramidal GLU cell Show Other

More Cells

Abstract single compartment conductance based cell Show Other

Model Currents

I Sodium Show Other
I A Show Other
I M Show Other
I h Show Other
I K Show Other

Model Receptors

AMPA Show Other
NMDA Show Other

Model Type

Synapse Show Other
Channel/Receptor Show Other
Neuron or other electrically excitable cell Show Other
Axon Show Other
Dendrite Show Other

Model Concept

Ion Channel Kinetics Show Other
Membrane Properties Show Other
Synaptic Integration Show Other
Synaptic Amplification Show Other
Place cell/field Show Other
Active Dendrites Show Other
Conductance distributions Show Other
Detailed Neuronal Models Show Other
Electrotonus Show Other
Markov-type model Show Other

Simulator software

NEURON Show Other

Model papers

Hsu CL, Zhao X, Milstein AD, Spruston N (2018) Show Other

Gene

hg folder name (applicable when in ModelDB hg)

Region Organism

Hippocampus Show Other

Model ID Number

Gap Junctions

Implemented by

Hsu, Ching-Lung [hsuc at janelia.hhmi.org] Show Other
Milstein, Aaron D. [aaronmil at stanford.edu] Show Other

Public Submitter Email Address

hsuc@janelia.hhmi.org

Other Neuron

Model Neurotransmitters

Glutamate Show Other

Other Receptor

Other Current

I Leak, I delayed-rectifier

Other Neurotransmitter

Other Model Type

Other Concept

Other Simulator

Other Implementer

Alternative Version

Citation

Hsu CL, Zhao X, Milstein AD, Spruston N. (2018). Persistent sodium current mediates steep voltage dependence of spatial coding in hippocampal pyramidal neurons. Neuron

Default File Notes

Other Gene

Simulation Platform ID

Has Model View

False

Component

RAM

Hide Auto-launch button

True

Run Protocols

ICG Channel Details

Species

Other categories referring to CA1 pyramidal neuron: Persistent Na current mediates steep synaptic amplification (Hsu et al 2018)

Revisions:	25
Last Time:	6/15/2018 4:47:44 PM
Reviewer:	Tom Morse - MoldelDB admin
Owner:	Tom Morse - MoldelDB admin