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The effects of intracellular calcium buffering on electrical tuning were studied in hair cells at apical and basal cochlear locations tuned to 100 and 300 Hz. Ca2+ imaging revealed about twice as many hotspots of Ca2+ entry during depolarization in high-frequency compared to low-frequency hair cells. It is suggested that each KCa channel is gated by Ca2+ entry through a few nearby Ca2+ channels, and that Ca2+ and KCa channels occupy, at constant channel density, a greater fraction of the membrane area in high-frequency cells than in low-frequency cells
  • Ricci AJ, Gray-Keller M, Fettiplace R (2000) Show Other
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Other categories referring to The effects of intracellular calcium buffering on electrical tuning were studied in hair cells at apical and basal cochlear locations tuned to 100 and 300 Hz. Ca2+ imaging revealed about twice as many hotspots of Ca2+ entry during depolarization in high-frequency compared to low-frequency hair cells. It is suggested that each KCa channel is gated by Ca2+ entry through a few nearby Ca2+ channels, and that Ca2+ and KCa channels occupy, at constant channel density, a greater fraction of the membrane area in high-frequency cells than in low-frequency cells
Neuronal Currents.Publication facts   (2)
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