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Model of the hippocampus over the sleep-wake cycle using Hodgkin-Huxley neurons (Aussel et al 2018)
Aussel Amélie
" ...we propose a computational model of the hippocampal formation based on a realistic topology and synaptic connectivity, and we analyze the effect of different changes on the network, namely the variation of synaptic conductances, the variations of the CAN channel conductance and the variation of inputs. By using a detailed simulation of intracerebral recordings, we show that this is able to reproduce both the theta-nested gamma oscillations that are seen in awake brains and the sharp-wave ripple complexes measured during slow-wave sleep. The results of our simulations support the idea that the functional connectivity of the hippocampus, modulated by the sleep-wake variations in Acetylcholine concentration, is a key factor in controlling its rhythms."
  • Aussel A, Buhry L, Tyvaert L, Ranta R (2018) Show Other
AusellEtAl2018
amelie.aussel@loria.fr
Brian2
False
False
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Last Time: 1/18/2019 3:19:15 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin