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Data
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Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
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Yunliang Zang
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"Climbing fibers (CFs) provide instructive signals driving cerebellar
learning, but mechanisms causing the variable CF responses in Purkinje
cells (PCs) are not fully understood. Using a new experimentally
validated PC model, we unveil the ionic mechanisms underlying
CF-evoked distinct spike waveforms on different parts of the PC. We
demonstrate that voltage can gate both the amplitude and the spatial
range of CF-evoked Ca2+ influx by the availability of K+
currents.
...
The voltage- and
branch-specific CF responses can increase dendritic computational
capacity and enable PCs to actively integrate CF signals."
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Neuron or other electrically excitable cell Show
Other
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Zang Y, Dieudonné S, De Schutter E (2018) Show
Other
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243446
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yunliang.zang@oist.jp
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Zang, Yunliang
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