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Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
Yunliang Zang
purkinje_pub [114400]
"Climbing fibers (CFs) provide instructive signals driving cerebellar learning, but mechanisms causing the variable CF responses in Purkinje cells (PCs) are not fully understood. Using a new experimentally validated PC model, we unveil the ionic mechanisms underlying CF-evoked distinct spike waveforms on different parts of the PC. We demonstrate that voltage can gate both the amplitude and the spatial range of CF-evoked Ca2+ influx by the availability of K+ currents. ... The voltage- and branch-specific CF responses can increase dendritic computational capacity and enable PCs to actively integrate CF signals."
  • Neuron or other electrically excitable cell Show Other
  • Zang Y, Dieudonné S, De Schutter E (2018) Show Other
yunliang.zang@oist.jp
Zang, Yunliang
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Revisions: 14
Last Time: 8/7/2018 11:43:22 AM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin