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Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Karthik Kumaravelu
"... High frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) suppresses parkinsonian motor symptoms and modulates cortical activity. ... Cortical evoked potentials (cEP) generated by STN DBS reflect the response of cortex to subcortical stimulation, and the goal was to determine the neural origin of cEP using a two-step approach. First, we recorded cEP over ipsilateral primary motor cortex during different frequencies of STN DBS in awake healthy and unilateral 6-OHDA lesioned parkinsonian rats. Second, we used a biophysically-based model of the thalamocortical network to deconstruct the neural origin of the cEP. The in vivo cEP included short (R1), intermediate (R2) and long-latency (R3) responses. Model-based cortical responses to simulated STN DBS matched remarkably well the in vivo responses. R1 was generated by antidromic activation of layer 5 pyramidal neurons, while recurrent activation of layer 5 pyramidal neurons via excitatory axon collaterals reproduced R2. R3 was generated by polysynaptic activation of layer 2/3 pyramidal neurons via the cortico-thalamic-cortical pathway. Antidromic activation of the hyperdirect pathway and subsequent intracortical and cortico-thalamo-cortical synaptic interactions were sufficient to generate cEP by STN DBS, and orthodromic activation through basal ganglia-thalamus-cortex pathways was not required. These results demonstrate the utility of cEP to determine the neural elements activated by STN DBS that might modulate cortical activity and contribute to the suppression of parkinsonian symptoms."
  • Neocortex M1 L6 pyramidal corticothalamic GLU cell Show Other
  • Neocortex M1 L5B pyramidal pyramidal tract GLU cell Show Other
  • Neocortex M1 L4 stellate GLU cell Show Other
  • Hodgkin-Huxley neuron Show Other
  • Neocortex layer 4 neuron Show Other
  • Neocortex fast spiking (FS) interneuron Show Other
  • Neocortex primary motor area pyramidal layer 5 corticospinal cell Show Other
  • Kumaravelu K, Oza CS, Behrend CE, Grill WM (2018) Show Other
  • Kumaravelu, Karthik [kk192 at duke.edu] Show Other
kk192@duke.edu
TCR, nRT neurons
29694280
False
False
Other categories referring to Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Revisions: 13
Last Time: 8/8/2018 10:47:59 AM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin