BrainPharm: Computational model - STDP and BDNF in CA1 spines (Solinas et al. 2019)

Computational model

Data

Name

STDP and BDNF in CA1 spines (Solinas et al. 2019)

Submitter name

Sergio Solinas

Pipeline ID

Model File

SolinasEtAl2019 [193364]

Notes

Storing memory traces in the brain is essential for learning and memory formation. Memory traces are created by joint electrical activity in neurons that are interconnected by synapses and allow transferring electrical activity from a sending (presynaptic) to a receiving (postsynaptic) neuron. During learning, neurons that are co-active can tune synapses to become more effective. This process is called synaptic plasticity or long-term potentiation (LTP). Timing-dependent LTP (t-LTP) is a physiologically relevant type of synaptic plasticity that results from repeated sequential firing of action potentials (APs) in pre- and postsynaptic neurons. T-LTP is observed during learning in vivo and is a cellular correlate of memory formation. T-LTP can be elicited by different rhythms of synaptic activity that recruit distinct synaptic growth processes underlying t-LTP. The protein brain-derived neurotrophic factor (BDNF) is released at synapses and mediates synaptic growth in response to specific rhythms of t-LTP stimulation, while other rhythms mediate BDNF-independent t-LTP. Here, we developed a realistic computational model that accounts for our previously published experimental results of BDNF-independent 1:1 t-LTP (pairing of 1 presynaptic with 1 postsynaptic AP) and BDNF-dependent 1:4 t-LTP (pairing of 1 presynaptic with 4 postsynaptic APs). The model explains the magnitude and time course of both t-LTP forms and allows predicting t-LTP properties that result from altered BDNF turnover. Since BDNF levels are decreased in demented patients, understanding the function of BDNF in memory processes is of utmost importance to counteract Alzheimer’s disease.

Model Neurons

Hippocampus CA1 pyramidal GLU cell Show Other

More Cells

Model Currents

I Na,t Show Other
I_KD Show Other
I K Show Other
I h Show Other
I A Show Other
I Calcium Show Other

Model Receptors

AMPA Show Other
NMDA Show Other

Model Type

Neuron or other electrically excitable cell Show Other
Synapse Show Other
Dendrite Show Other

Model Concept

Facilitation Show Other
Long-term Synaptic Plasticity Show Other
Short-term Synaptic Plasticity Show Other
STDP Show Other

Simulator software

NEURON Show Other

Model papers

Solinas SMG, Edelmann E, Leßmann V, Migliore M (2019) Show Other

Gene

hg folder name (applicable when in ModelDB hg)

244412

Region Organism

Hippocampus Show Other

Model ID Number

Gap Junctions

Implemented by

Solinas, Sergio [solinas at unipv.it] Show Other
Migliore, Michele [Michele.Migliore at Yale.edu] Show Other

Public Submitter Email Address

smgsolinas@gmail.com

Other Neuron

Model Neurotransmitters

Glutamate Show Other

Other Receptor

TrkB

Other Current

Other Neurotransmitter

Other Model Type

Spine

Other Concept

Other Simulator

Other Implementer

Sergio Solinas Michele Migliore

Alternative Version

Citation

Default File Notes

Other Gene

Simulation Platform ID

Has Model View

False

Component

RAM

Hide Auto-launch button

False

Run Protocols

ICG Channel Details

Species

Other categories referring to STDP and BDNF in CA1 spines (Solinas et al. 2019)

Revisions:	39
Last Time:	1/30/2023 1:32:23 PM
Reviewer:	Rui Li
Owner:	Tom Morse - MoldelDB admin