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Human sleep-wake regulatory network model (Gleit et al 2013, Booth et al 2017)
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Victoria Booth
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A physiologically-based mathematical model of a sleep-wake regulatory network model for human sleep. The model simulates neurotransmitter-mediated interactions among hypothalamic and brainstem neuronal populations that promote wake, rapid eye movement (REM) sleep and non-REM (NREM) sleep. A neuronal population firing rate model formalism is used. The circadian rhythm pacemaker neuronal population, the suprachiasmatic nucleus (SCN), modulates activity in the wake- and sleep-promoting populations to entrain sleep-wake behavior to the ~24h circadian rhythm. A circadian clock oscillator model drives a 24h variation in the SCN firing rate and can be entrained to an externally imposed light:dark cycle. The default parameters replicate typical human sleep entrained to an external 14h:10h light:dark cycle
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Gleit RD, Diniz Behn CG, Booth V (2013) Show
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Booth V, Xique I, Diniz Behn C (2017) Show
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Booth, Victoria [vbooth at umich.edu] Show
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vbooth@umich.edu
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Booth, Victoria
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Gleit, Diniz Behn and Booth, J Biol Rhythms 28:339-355, 2013
Booth, Xique and Diniz Behn, SIAM J Appl Dyn Sys 16(2):1089-1112, 2017
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