BrainPharm: Computational model - Determinants of the intracellular and extracellular waveforms in DA neurons (Lopez-Jury et al 2018)

Computational model

Data

Name

Determinants of the intracellular and extracellular waveforms in DA neurons (Lopez-Jury et al 2018)

Submitter name

Luciana López Jury

Pipeline ID

Model File

DAnotch_AIS [159405]

Notes

To systematically address the contribution of AIS, dendritic and somatic compartments to shaping the two-component action potentials (APs), we modeled APs of male mouse and rat dopaminergic neurons. A parsimonious two-domain model, with high (AIS) and lower (dendro-somatic) Na+ conductance, reproduced the notch in the temporal derivatives, but not in the extracellular APs, regardless of morphology. The notch was only revealed when somatic active currents were reduced, constraining the model to three domains. Thus, an initial AIS spike is followed by an actively generated spike by the axon-bearing dendrite (ABD), in turn followed mostly passively by the soma. Larger AISs and thinner ABD (but not soma-to-AIS distance) accentuate the AIS component.

Model Neurons

Substantia nigra pars compacta DA cell Show Other

More Cells

Model Currents

I Calcium Show Other
I K,Ca Show Other
Na/K pump Show Other
I L high threshold Show Other
I T low threshold Show Other
I A Show Other
I N Show Other
I Na,t Show Other
I K Show Other

Model Receptors

Model Type

Extracellular Show Other
Dendrite Show Other
Neuron or other electrically excitable cell Show Other

Model Concept

Action Potential Initiation Show Other
Pacemaking mechanism Show Other
Temporal Pattern Generation Show Other
Oscillations Show Other
Extracellular Fields Show Other

Simulator software

NEURON Show Other

Model papers

López-Jury L, Meza RC, Brown MTC, Henny P, Canavier CC (2018) Show Other

Gene

hg folder name (applicable when in ModelDB hg)

Region Organism

Basal ganglia Show Other

Model ID Number

Gap Junctions

Implemented by

Lopez-Jury, Luciana [lucianalopezjury at gmail.com] Show Other
Canavier, CC Show Other

Public Submitter Email Address

lucianalopezjury@gmail.com

Other Neuron

Model Neurotransmitters

Other Receptor

Other Current

Other Neurotransmitter

Other Model Type

Other Concept

Other Simulator

Other Implementer

Alternative Version

Citation

PubMed: 30104340 DOI:10.1523/JNEUROSCI.0651-18.2018

Default File Notes

Other Gene

Simulation Platform ID

Has Model View

False

Component

RAM

Hide Auto-launch button

False

Run Protocols

ICG Channel Details

Species

Other categories referring to Determinants of the intracellular and extracellular waveforms in DA neurons (Lopez-Jury et al 2018)

Revisions:	8
Last Time:	8/21/2018 11:43:46 AM
Reviewer:	Tom Morse - MoldelDB admin
Owner:	Tom Morse - MoldelDB admin