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Active dendrites shape signaling microdomains in hippocampal neurons (Basak & Narayanan 2018)
Reshma Basak
The spatiotemporal spread of biochemical signals in neurons and other cells regulate signaling specificity, tuning of signal propagation, along with specificity and clustering of adaptive plasticity. Theoretical and experimental studies have demonstrated a critical role for cellular morphology and the topology of signaling networks in regulating this spread. In this study, we add a significantly complex dimension to this narrative by demonstrating that voltage-gated ion channels (A-type Potassium channels and T-type Calcium channels) on the plasma membrane could actively amplify or suppress the strength and spread of downstream signaling components. We employed a multiscale, multicompartmental, morphologically realistic, conductance-based model that accounted for the biophysics of electrical signaling and the biochemistry of calcium handling and downstream enzymatic signaling in a hippocampal pyramidal neuron. We chose the calcium – calmodulin – calcium/calmodulin-dependent protein kinase II (CaMKII) – protein phosphatase 1 (PP1) signaling pathway owing to its critical importance to several forms of neuronal plasticity, and employed physiologically relevant theta-burst stimulation (TBS) or theta-burst pairing (TBP) protocol to initiate a calcium microdomain through NMDAR activation at a synapse.
  • Hippocampus CA1 pyramidal GLU cell Show Other
Basak_Narayayanan_2018
  • Basak, Reshma [reshmab at iisc.ac.in] Show Other
  • Narayanan, Rishikesh [rishi at iisc.ac.in] Show Other
reshmab@iisc.ac.in
Realistic morphology
Calcium Microdomain
Reshma Basak (reshmab@iisc.ac.in), Rishikesh Narayanan (rishi@iisc.ac.in)
Basak R, Narayanan R (in Press), Active dendrites regulate the spatiotemporal spread of signaling microdomains, Plos. Comp. Biol
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Revisions: 12
Last Time: 10/8/2018 11:45:17 AM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin