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Conductance based model for short term plasticity at CA3-CA1 synapses (Mukunda & Narayanan 2017)
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Chinmayee L M
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We develop a new biophysically rooted, physiologically constrained conductance-based synaptic model to mechanistically account for short-term facilitation and depression, respectively through residual calcium and transmitter depletion kinetics. The model exhibits different synaptic filtering profiles upon changing certain parameters in the base model. We show degenercy in achieving similar plasticity profiles with different presynaptic parameters. Finally, by virtually knocking out certain conductances, we show the differential contribution of conductances.
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Hippocampus CA3 pyramidal GLU cell Show
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Mukunda, Chinmayee L [chinmayeelm at gmail.com] Show
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chinmayeelm@gmail.com
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I Na, I CaL
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Neurotransmitter dynamics
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Chinmayee L Mukunda
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Mukunda, C. L. and Narayanan, R. (2017), Degeneracy in the regulation of short-term plasticity and synaptic filtering by presynaptic mechanisms. J Physiol, 595: 2611-2637. doi:10.1113/JP273482
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