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Striatal Spiny Projection Neuron, inhibition enhances spatial specificity (Dorman et al 2018)
Daniel Dorman
We use a computational model of a striatal spiny projection neuron to investigate dendritic spine calcium dynamics in response to spatiotemporal patterns of synaptic inputs. We show that spine calcium elevation is stimulus-specific, with supralinear calcium elevation in cooperatively stimulated spines. Intermediate calcium elevation occurs in neighboring non-stimulated dendritic spines, predicting heterosynaptic effects. Inhibitory synaptic inputs enhance the difference between peak calcium in stimulated spines, and peak calcium in non-stimulated spines, thereby enhancing stimulus specificity.
  • Neuron or other electrically excitable cell Show Other
  • Dorman DB, Jedrzejewska-Szmek J, Blackwell KT (2018) Show Other
modeldb_eLife2018
ddorman@gmu.edu
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Revisions: 15
Last Time: 12/12/2018 4:06:18 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin