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Data
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Stimulated and physiologically induced APs: frequency and fiber diameter (Sadashivaiah et al 2018)
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Tom Morse - MoldelDB admin
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"...
In this study, we
aim to quantify the effects of stimulation frequency and fiber
diameter on AP (Action Potential) interactions involving collisions and loss of
excitability. We constructed a mechanistic model of a myelinated nerve
fiber receiving two inputs: the underlying physiological activity at
the terminal end of the fiber, and an external stimulus applied to the
middle of the fiber. We define conduction reliability as the
percentage of physiological APs that make it to the somatic end of the
nerve fiber. At low input frequencies, conduction reliability is
greater than 95% and decreases with increasing frequency due to an
increase in AP interactions. Conduction reliability is less sensitive
to fiber diameter and only decreases slightly with increasing fiber
diameter. Finally, both the number and type of AP interactions
significantly vary with both input frequencies and fiber
diameter.
..."
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Sadashivaiah V, Sacré P, Guan Y, Anderson WS, Sarma SV (2018) Show
Other
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tom.morse@yale.edu
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