Computational model
Bursting in dopamine neurons (Li YX et al 1996)
Tom Morse - MoldelDB admin [102253]
"Burst firing of dopaminergic neurons of the substantia nigra pars compacta can be induced in vitro by the glutamate agonist N-methyl-D-aspartate. It has been suggested that the interburst hyperpolarization is due to Na+ extrusion by a ouabain-sensitive pump (Johnson et al. (1992) Science 258, 665-667). We formulate and explore a theoretical model, with a minimal number of currents, for this novel mechanism of burst generation. This minimal model is further developed into a more elaborate model based on observations of additional currents and hypotheses about their spatial distribution in dopaminergic neurons ... Responses of the model to a number of electrophysiological and pharmacological stimuli are consistent with known responses observed under similar conditions. ..."
  • Neuron or other electrically excitable cell Show Other
  • Li YX, Bertram R, Rinzel J (1996) Show Other
Li et al 1996
Other categories referring to Bursting in dopamine neurons (Li YX et al 1996)
Revisions: 3
Last Time: 11/29/2018 4:44:03 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin