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Data
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Sleep deprivation in the ascending arousal system (Phillips & Robinson 2008)
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Tom Morse - MoldelDB admin
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"A physiologically based quantitative model of the human ascending
arousal system is used to study sleep deprivation after being
calibrated on a small set of experimentally based criteria. The model
includes the sleep–wake switch of mutual inhibition between nuclei
which use monoaminergic neuromodulators, and the ventrolateral
preoptic area. The system is driven by the circadian rhythm and sleep
homeostasis.
We use a small number of experimentally derived criteria
to calibrate the model for sleep deprivation, then investigate model
predictions for other experiments, demonstrating the scope of
application.
...
The form of the homeostatic drive suggests
that periods of wake during recovery from sleep deprivation are phases
of relative recovery, in the sense that the homeostatic drive
continues to converge toward baseline levels.
This undermines the
concept of sleep debt, and is in agreement with experimentally
restricted recovery protocols. Finally, we compare our model to the
two-process model, and demonstrate the power of physiologically based
modeling by correctly predicting sleep latency times following
deprivation from experimental data.
"
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tom.morse@yale.edu
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Phillips Robinson 2008
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