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Data
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A multiscale approach to analyze circadian rhythms (Vasalou & Henson, 2010) (SBML)
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Tom Morse - MoldelDB admin
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" ... We developed a firing rate code model to incorporate known
electrophysiological properties of SCN (suprachiasmatic nucleus)
pacemaker cells, including circadian dependent changes in membrane
voltage and ion conductances. Calcium dynamics were included in the
model as the putative link between electrical firing and gene
expression. Individual ion currents exhibited oscillatory patterns
matching experimental data both in current levels and phase
relationships. VIP and GABA neurotransmitters, which encode synaptic
signals across the SCN, were found to play critical roles in daily
oscillations of membrane excitability and gene expression. Blocking
various mechanisms of intracellular calcium accumulation by simulated
pharmacological agents (nimodipine, IP3- and ryanodine-blockers)
reproduced experimentally observed trends in firing rate dynamics and
core-clock gene transcription. The intracellular calcium concentration
was shown to regulate diverse circadian processes such as firing
frequency, gene expression and system periodicity. The model predicted
a direct relationship between firing frequency and gene expression
amplitudes, demonstrated the importance of intracellular pathways for
single cell behavior and provided a novel multiscale framework which
captured characteristics of the SCN at both the electrophysiological
and gene regulatory levels."
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Neuron or other electrically excitable cell Show
Other
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tom.morse@yale.edu
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