Computational model
Pancreatic Beta Cell signalling pathways (Fridlyand & Philipson 2016) (MATLAB)
Seeraja Konnur
This is a 3rd party implementation of Fridlyand & Philipson 2016 who's abstract begins "Insulin secretory in pancreatic beta-cells responses to nutrient stimuli and hormonal modulators include multiple messengers and signaling pathways with complex interdependencies. Here we present a computational model that incorporates recent data on glucose metabolism, plasma membrane potential, G-protein-coupled-receptors (GPCR), cytoplasmic and endoplasmic reticulum calcium dynamics, cAMP and phospholipase C pathways that regulate interactions between second messengers in pancreatic beta-cells. The values of key model parameters were inferred from published experimental data. The model gives a reasonable fit to important aspects of experimentally measured metabolic and second messenger concentrations and provides a framework for analyzing the role of metabolic, hormones and neurotransmitters changes on insulin secretion. Our analysis of the dynamic data provides support for the hypothesis that activation of Ca2+-dependent adenylyl cyclases play a critical role in modulating the effects of glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and catecholamines. ..."
  • Fridlyand LE, Philipson LH (2016) Show Other
Na+, K+ channels
Athil Althaf A Z, Urvi Mishra and Seeraja Konnur
Other categories referring to Pancreatic Beta Cell signalling pathways (Fridlyand & Philipson 2016) (MATLAB)
Revisions: 33
Last Time: 3/11/2019 2:56:31 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin