BrainPharm: Computational model - Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)

Computational model

Data

Name

Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)

Submitter name

Peng Penny Gao

Pipeline ID

Model File

plateau-potentials [904997]

Notes

Our model was built on a reconstructed Layer 5 pyramidal neuron of the rat medial prefrontal cortex, and constrained by 4 sets of experimental data: (i) voltage waveforms obtained at the site of the glutamatergic input in distal basal dendrite, including initial sodium spikelet, fast rise, plateau phase and abrupt collapse of the plateau; (ii) a family of voltage traces describing dendritic membrane responses to gradually increasing intensity of glutamatergic stimulation; (iii) voltage waveforms of backpropagating action potentials in basal dendrites (Antic, 2003); and (iv) the change of backpropagating action potential amplitude in response to drugs that block Na+ or K+ channels (Acker and Antic, 2009). Both, synaptic AMPA/NMDA and extrasynaptic NMDA inputs were placed on basal dendrites to model the induction of local regenerative potentials termed "glutamate-mediated dendritic plateau potentials". The active properties of the cell were tuned to match the voltage waveform, amplitude and duration of experimentally observed plateau potentials. The effects of input location, receptor conductance, channel properties and membrane time constant during plateau were explored. The new model predicted that during dendritic plateau potential the somatic membrane time constant is reduced. This and other model predictions were then tested in real neurons. Overall, the results support our theoretical framework that dendritic plateau potentials bring neuronal cell body into a depolarized state ("UP state"), which lasts 200 - 500 ms, or more. Plateau potentials profoundly change neuronal state -- a plateau potential triggered in one basal dendrite depolarizes the soma and shortens membrane time constant, making the cell more susceptible to action potential firing triggered by other afferent inputs. Plateau potentials may allow cortical pyramidal neurons to tune into ongoing network activity and potentially enable synchronized firing, to form active neural ensembles.

Model Neurons

Neocortex L5/6 pyramidal GLU cell Show Other

More Cells

Model Currents

I A Show Other
I K Show Other
I h Show Other
I K,Ca Show Other

Model Receptors

Glutamate Show Other
NMDA Show Other

Model Type

Dendrite Show Other
Neuron or other electrically excitable cell Show Other

Model Concept

Action Potentials Show Other
Active Dendrites Show Other
Calcium dynamics Show Other
Axonal Action Potentials Show Other
Dendritic Bistability Show Other
Detailed Neuronal Models Show Other
Membrane Properties Show Other
Synaptic Integration Show Other

Simulator software

NEURON Show Other
Python Show Other

Model papers

Gao PP, Graham JW, Zhou WL, Jang J, Angulo SL, Dura-Bernal S, Hines ML, Lytton W, Antic SD (2020) Show Other

Gene

hg folder name (applicable when in ModelDB hg)

Region Organism

Prefrontal cortex (PFC) Show Other
Neocortex Show Other

Model ID Number

Gap Junctions

Implemented by

Antic, Srdjan [antic at neuron.uchc.edu] Show Other
Gao, Peng [peng at uchc.edu] Show Other

Public Submitter Email Address

penggao.1987@gmail.com

Other Neuron

Model Neurotransmitters

Glutamate Show Other

Other Receptor

Other Current

Other Neurotransmitter

Other Model Type

Other Concept

Other Simulator

Other Implementer

Gao, Peng [penggao.1987 at mail.com]

Alternative Version

Citation

Default File Notes

Other Gene

Simulation Platform ID

Has Model View

False

Component

RAM

Hide Auto-launch button

False

Run Protocols

ICG Channel Details

Species

Other categories referring to Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)

Revisions:	10
Last Time:	10/28/2020 12:26:49 PM
Reviewer:	Robert A McDougal
Owner:	Tom Morse - MoldelDB admin