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Inhibitory neuron plasticity as a mechanism for ocular dominance plasticity (Bono & Clopath 2019)
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Jacopo Bono
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"Ocular dominance plasticity is a well-documented phenomenon
allowing us to study properties of cortical
maturation. Understanding this maturation might be an important
step towards unravelling how cortical circuits function. However,
it is still not fully understood which mechanisms are responsible
for the opening and closing of the critical period for ocular
dominance and how changes in cortical responsiveness arise after
visual deprivation. In this article, we present a theory of
ocular dominance plasticity. Following recent experimental work,
we propose a framework where a reduction in inhibition is
necessary for ocular dominance plasticity in both juvenile and
adult animals. In this framework, two ingredients are crucial to
observe ocular dominance shifts: a sufficient level of inhibition
as well as excitatory-to-inhibitory synaptic plasticity. In our
model, the former is responsible for the opening of the critical
period, while the latter limits the plasticity in adult
animals. Finally, we also provide a possible explanation for the
variability in ocular dominance shifts observed in individual
neurons and for the counter-intuitive shifts towards the closed
eye."
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jacopobono@hotmail.com
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